The Power

The Power

The power of Dynamic PGx and The Opioid Factor is that the results and drug details of all of this complicated information for a specific patient taking specific medications are provided to the doctor or pharmacist in an easily-utilized format. Multifactorial PGx information assists the caregiver in prescribing the best treatment at the best dosage for that patient with the lowest risk of an ADR.  Known conflicts between medications including those conflicts between certain genes and the same medications are presented. Therefore, such conflicts have an increased probability of being avoided.

 

How Dynamic PGx makes a difference: 

  1. Dynamic PGx and The Opioid Factor, utilizing multiple independent databases, present multifactorial relationships in a simplified presentation to the user; manually searching the written report no longer is required.

  2. Dynamic PGx and The Opioid Factor present a dynamic and interactive interface that provides real-time information. 

  3. It is not possible to manually analyze and understand all possible combinations and interactions with all of the possible variable relationships from the current standard printed report currently available. There are 15,625 possible combinations of six CYPs (Cytochrome P450s) each with five functional categories (normal, intermediate, poor, multiple copies and hyper-inducer) from the type of static printed report currently provided.

  4. With Dynamic PGx drug-CYP relationships are defined, their complexity simplified, therefore decreasing the probability of error with the new drug being prescribed. 

  5. Existing protocols contain prescription drugs, over-the-counter drugs, foods, nutrients, recreational drugs, and exotoxins, that individually and collectively represent the potential influence of a CYP's expression by a process called phenoconversion.

    1. Example: a strong inhibitor can be such that a gene that expresses without the presence of the strong inhibitor is normal. However, the extraneous inhibition can compromise the CYPs such that it presents as a poor metabolizer.

    2. Although written reports provide a list of influencing factors, essential elements such as the strength of an inhibitor are missing.

  6. The Rx Factor software has an automated alternative drug selection routine (GPS Gene Pathway Substitution) that recognizes an aberrant CYP functional relationship as it relates to the new drug entry. It queries the same class category drug list and presents an alternative drug/CYP relationship with normal function.

 

At last, a highly individualized treatment protocol can be provided for each patient that helps avoid the costs of unintended consequences, ADRs, in terms of both dollars and human lives. The antiquated process of prescribing medications without considering peer-reviewed pharmacogenomic information that is presently available is irresponsible and in conflict with the Hippocratic oath: Doctor, do no harm

 

In other words: With Dynamic PGx, the RIGHT drug, at the RIGHT dose, at the RIGHT time, for the RIGHT patient can now be prescribed.

Converting a potentially dangerous guess into a genetically-informed decision.

© 2020 NeX Step, Inc. All Rights Reserved

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